Severe chronic venous insufficiency (CVI) is a debilitating disease afflicting millions of people around the world. It causes a variety of symptoms including swollen, painful legs, edema, cramps, varicose veins, and ulcers. These symptoms are caused by poor circulation, which results in blood accumulating in the legs and impairs patients’ ability to walk – seriously impacting quality of life and imposing considerable costs on healthcare systems for wound care.
However, there is currently, no efficient solution. “Compression stockings remains the standard form of treatment for chronic venous insufficiency patients but the effect on ulcer recurrence and symptom relief is quite insignificant.” explains Dr. Antonio Rosales, head of the National Unit For Reconstructive Deep Venous Surgery at the Oslo University hospital (NOVI/OUS) and leading clinical collaborator of ClexBio. “An engineered vein graft would be an absolute game-changer for millions of CVI patients”, he adds.
ClexBio intends to draw on its expertise in regenerative medicine to tackle the root cause of CVI. The company has teamed up with the specialists in automations from CSEM to develop an automated process for engineering functional vein grafts comprised of pure human tissue material that integrate into the patient’s body and turn into real, living tissue. ClexBio has received 20 million Norwegian kroner (around 2,010,000 Swiss francs) in funding for this research from the government of Norway.